DEVELOPMENTAL TOXICITY OF ANTICANCER AGENTS
نویسندگان
چکیده
منابع مشابه
Alkaloids as anticancer agents
Alkaloids are a class of naturally occurring organic nitrogen containing bases. Typical alkaloids are derived from plant sources, they are basic, they contain one or more nitrogen atoms (usually in a heterocyclic ring) and they usually have a marked physiological action on man or other animals. Alkaloids have potent anticancer activity against various cancers. In this review mainly discussed ab...
متن کاملFlavonoids: promising anticancer agents.
Flavonoids are polyphenolic compounds that are ubiquitously in plants. They have been shown to possess a variety of biological activities at nontoxic concentrations in organisms. The role of dietary flavonoids in cancer prevention is widely discussed. Compelling data from laboratory studies, epidemiological investigations, and human clinical trials indicate that flavonoids have important effect...
متن کاملPreclinical toxicology of anticancer agents.
The use of animal toxicology as a potential predictive system for drug toxicity in man is particularly important to the field of cancer chemotherapy because of several major clinical considerations (11). The nature of the growth characteristics of tumors in man requires that repeated courses of treatment be given oven extended periods of time; this approach carries with it an increased risk for...
متن کاملPharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants
Molecular modeling has been employed in the search for lead compounds of chemotherapy to fight cancer. In this study, pharmacophore models have been generated and validated for use in virtual screening protocols for eight known anticancer drug targets, including tyrosine kinase, protein kinase B β, cyclin-dependent kinase, protein farnesyltransferase, human protein kinase, glycogen synthase kin...
متن کاملAntitumor activity and bone marrow toxicity of aminoglucose mustard anticancer agents in mice.
In previous structure-activity studies, we have demonstrated that attachment of a glucose molecule to the chloroethylnitrosourea cytotoxic group produces a compound with reduced murine bone marrow toxicity and retention of full antitumor activity. To further define this protective role conferred by the glucose moiety in bone marrow cells, we have replaced the nitrosourea cytotoxic group with an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1991
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.16.supplementii_31